HFMD is a mild,contagious viral infection normally in children under five years old.Common viruses which cause HFMD include Enterovirus 71(EV71),Coxsackievirus A16(CA16),Coxsackievirus A10(CA10) and Coxsackievirus A6(CA6).These viruses have caused over 90% of HFMD cases in China.Currently,EV71 inactivated vaccines are the only HFMD vaccines approved globally and in China.In 2020,HFMD has the fourth highest incidence rate among notifiable infectious diseases in China with more than 760,000 cases reported.We are leveraging our protein engineering technology to develop a multi-valent hand-foot-and-mouth vaccine,REC605,with increased serotype coverage of EV71,CA16,CA10 and CA6 and enhanced protection.We plan to submit the IND application to the NMPA for REC605 in 2023 and the BLA application in 2026.
REC605 -- Recombinant tetravalent HFMD vaccine
- A wider range of serotypes can be covered by recombinant protein technology routes, which cannot be achieved by traditional vaccine technology routes
- REC605 had higher coverage and stronger protection of EV71, CA16, CA10 and CA6 serotypes
- With the development of recombinant protein tetravalent vaccines against EV71, CA16, CA10 and CA6, China's HFMD vaccine market is expected to witness rapid growth in the future